Enfamil Gentlease vs. Similac Total Comfort [Recap 2023] (2023)

Looking for an infant formula for quick relief from stomach problems? Enfamil Gentlease and Similac Total Comfort claim fast relief, but which is better?

Let us support you in your decision with our detailed test.Enfamil Gentlease versus Similac Total ComfortAnalyse!

Restlessness when feeding can cause a lot of stress for parents and babies. It's difficult when every feeding is followed by a fuss and taking a bottle seems to cause your child pain.

Infant formulas such as Enfamil Gentlease and Similac Total Comfort offer a possible solution. These formulas are designed to be easy on the stomach as they use smaller proteins that are easier to digest. But how well do they really work?

In this guide we take a close look at Enfamil Gentlease and Similac Total Comfort to see how popular infant formula compares. If sensitive stomachs are causing you feeding issues, we think these formulas might help!

And if you love itSimilac Total Comfort versus Enfamil Gentleasecheck, be sure to check out our guidesbest formula that tastes like breast milk,Similac Pro Total Comfort Vs Pro Sensitive,Similac Sensitive Vs Total Comfort, zEnfamil Gentlease Vs Similac Sensitive! You might even like our reviewEnfamil NeuroPro vs. Similac Pro Advance!

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Enfamil Gentlease vs. Similac Total Comfort [Recap 2023] (1)

Enfamil Gentlease vs. Similac Total Comfort

In this section we look at what Enfamil Gentlease and Similac Total Comfort claim to do.

All about Enfamil Gentlease

Enfamil Gentlease vs. Similac Total Comfort [Recap 2023] (2)

Gentle on the stomach, Enfamil Gentlease is designed to allow babies with sensitive stomachs to eat fully. For babies struggling with vomiting, restlessness and crying, Enfamil Gentlease can help with digestion and quickly relieve stress during feeding time.

Enfamil Gentlease uses proteins that have already been partially degraded. These partially hydrolyzed skim milk and whey proteins easily pass through the digestive system and cause less pain and discomfort for the baby. If you have found that standard formulas lead to tears and excitement, Enfamil Gentlease can be an effective solution.

And you don't have to wait long to see the result! Because of these smaller proteins, you can see the benefits of switching to Gentlease in just 24 hours!

Enfamil Gentlease is a brain-building formula containing a special blend of expert-recommended choline and DHA. Gentlease can give your child the best start in life!


  • Enfamil Gentlease uses partially hydrolyzed proteins that are smaller and easier for the body to digest.
  • It can reduce spitting up and relieve crying and fussing in babies.
  • Fast acting, you can see Gentlease results in just 24 hours.
  • Contains choline and DHA, which support healthy brain development.
  • Easy to mix and with a smooth and pleasant taste.

In contrast

  • Enfamil Gentlease is more expensive than similar easily digestible formulas.

You might also like our guidesEnfamil Gentlease alternativesebest formula for spit and gas!

(Video) Enfamil Gentlease vs Similac Sensitive Which is Best

All about Similac Total Comfort

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Similac Total Comfort is an infant formula designed to facilitate digestion in sensitive stomachs. As a complete feed, Total Comfort uses the prebiotic 2'-FL HMO to closely mimic the composition of breast milk.

Similac Total Comfort uses hydrolyzed proteins to create a formula that copes better with growing digestive systems. This is ideal for babies who are struggling with tummy problems and may find feeding time stressful. Because proteins are already partially digested, they put much less pressure on the body.

As a complete diet, Similac Total Comfort offers your little one everything they need for healthy growth. This food contains nutrients like DHA and Lutein for brain and eye development and is a great start for babies.

Total Comfort may not seem familiar to you even if you use Similac consistently - American mothers are much more likely to recognize Similac Pro-Total Comfort! They essentially have the same formula, only Total Comfort is made in Spain (and sold with FDA approval).

Although Similac Total Comfort is good for the stomach, some parents have found that it has a strong odor and is prone to lumps.


  • Made from partially hydrolyzed whey proteins that are gentle on the growing digestive system.
  • Contains 2'-FL HMO, a prebiotic that supports the immune system.
  • Contains DHA and Lutein for healthy brain and eye development.
  • Total Comfort does not contain palm olein oil, which can limit calcium absorption.
  • An affordable formula for sensitive stomachs.

In contrast

  • Parents have found that Total Comfort tends to clump and needs to be mixed thoroughly.
  • As an imported formula, it can be difficult to buy from time to time, so you need to make a formula change.

Similac Total Comfort infant formula


$ 36,49$32.97 ($1.14/ounce)

Enfamil Gentlease vs. Similac Total Comfort [Recap 2023] (5)

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Similarities and differences between Enfamil Gentlease and Similac Total Comfort

Designed to ease digestion, there are many similarities between Enfamil Gentlease and Similac Total Comfort. Here, we'll examine those similarities—and the important differences—in more detail.

A complete food for picky babies

Enfamil Gentlease and Similac Total Comfort are formulas designed to soothe restless tummies and alleviate digestive problems. They are recommended for babies who are fussy about food or who suffer from bloating and other stomach upsets.

Both Enfamil Gentlease and Similac Total Comfort are packed with the nutrients your child needs for healthy growth and development. But because of the gentle formulation, they can deliver those nutrients in a way that's less likely to upset sensitive stomachs.

Whether you choose Enfamil Gentlease or Similac Total Comfort, both brands are industry leaders and have been trusted by parents for decades. Enfamil is the number one brand recommended by pediatricians, and Similac is the number one brand for hospital-fed infants. So you know your baby's feeding is in capable hands!

Easily digestible proteins

What makes Enfamil Gentlease and Similac Total Comfort so good for babies with digestive problems? The key to the easy digestibility of both brands is the use of partially hydrolyzed proteins.

Hydrolysis is essentially the process of breaking down a chemical. Hydrolysis of proteins is used in infant formula. This makes proteins smaller so they don't overwhelm a still-developing digestive system.

These partially hydrolyzed proteins also make the formulas slightly closer to breast milk than non-hydrolyzed formulas because the milk molecules are smaller.

Enfamil Gentlease uses a blend of partially hydrolyzed skim milk and concentrated whey protein solids, and Similac Total Comfort uses partially hydrolyzed whey protein.

Gentlease and Total Comfort use partial hydrolysis instead of full hydrolysis. They are not hypoallergenic and therefore may not be suitable for severe allergic reactions. Both also contain (very) small amounts of lactose.

Support of the immune system

Similac has added 2'-FL HMO to the Total Comfort formula to provide additional immune support for the growing body. 2'-FL HMO is a human milk oligosaccharide, also known as a prebiotic, that is naturally found in breast milk. This directly helps fuel the immune response in the gut. The inclusion of 2'-FL HMO brings the formula closer to breast milk for more complete nutrition.

That's not to say Enfamil Gentlease doesn't support a growing immune system - it contains the nutrients your baby needs to take on the world! But the Gentlease lacks the added boost of support from the 2'-FL HMO.

nutrients for the brain

Both Enfamil Gentlease and Similac Total Comfort contain nutrients to support healthy brain development. Enfamil Gentlease has a blend of DHA and Choline for brain support, while Similac Total Comfort uses DHA and Lutein for brain and eye development.

quick action

When your baby is having trouble feeding, you want to get it taken care of as soon as possible. Both Enfamil Gentlease and Similac Total Comfort claim to work in just 24 hours, making it easy to shake up within a day of use.

(Video) What is the problem with Enfamil?

This is due to broken down proteins, which the body can adapt to quickly.

Where is it made?

Both Similac and Enfamil are American brands and most of their formulas are made in America. However, Similac Total Comfort is an imported formula manufactured in Spain. Similac started importing Total Comfort into the US to meet supply chain needs!

Similac Total Comfort may be an imported formula but has been approved by the FDA for sale in the United States. It may come as a surprise to see imported formulas, but Similac Total Comfort has had to pass the same rigorous safety tests as Enfamil Gentlease.

taste and texture

You can never tell how a baby will react to the formula, so don't let taste dictate your choice. However, if you're really having trouble deciding between the two, parents have found that Enfamil Gentlease has the best smell and taste.

Although both formulas are easy to mix, parents have found that Similac Total Comfort is more prone to clumping than Enfamil Gentlease. Gentlease dissolves better and less often needs a good shake during feeding.


For parents on a tight budget, the Similac Total Comfort is usually the cheaper choice. Enfamil Gentlease is only slightly more expensive, but these small differences could lead to repeat purchases.

It's often best to buy formula in bulk (once you know it works for your baby). Buying in bulk avoids regular visits to the store and can often save money. Parents may find it easier to buy Enfamil Gentlease (which is made in the USA) than Similac Total Comfort (which is imported from Spain).

Final Thoughts on Similac Total Comfort vs. Enfamil Gentlease

Enfamil Gentlease and Similac Total Comfort are formulas that use partially hydrolyzed proteins to ease digestion for sensitive stomachs.

Overall, we prefer the performance of the Similac Total Comfort. It contains all the nutrients needed for complete nutrition plus 2'-FL HMO which may support a developing immune system. It is also typically less expensive than Enfamil Gentlease and contains no palm olein oil.

However, Enfamil Gentlease has its advantages. It's easier to mix than Total Comfort and babies often prefer the taste.

Sensitive stomachs can be a nightmare and both Similac Total Care and Enfamil Gentlease offer potential solutions. We hope this guide can help you eat.

And if you want to check out more of our guides, we encourage you to check out these guides atInfant formula expires?,how to keep the bottle warm at nighteHow to warm baby bottles on the go. Or even our guides to thosebest bottles for tongue tie, zbest bottles for reflux.

Enfamil Gentlease vs. Similac Total Comfort [Recap 2023] (6)

buy now

(Video) ⏺️The Best Baby Formula: Enfamil VS Similac

Similac Total Comfort infant formula

$ 36,49$32.97 ($1.14/ounce)

Enfamil Gentlease vs. Similac Total Comfort [Recap 2023] (7)

23.02.2023 23h51 |

Enfamil Gentlease vs. Similac Total Comfort [Recap 2023] (8)

Enfamil Gentlease vs. Similac Total Comfort [Recap 2023] (9)

Allison Banfield

Allison Banfield, a seasoned mother of two, wife, author, editor and passionate parenting advocate! With a Masters in Public Health, a Bachelors in Health Promotion, a long career in health and safety and 10 years of hands-on experience using, researching and testing baby products, Allison enjoys using her experience as a mother to support and encourage others Parents.

(Video) When can I give my baby Enfamil AR?


Is Similac total comfort the same as Enfamil Gentlease? ›

The Winner: Similac Pro-Total Comfort

The two formulas have different protein sources, which may affect your baby's comfort: Gentlease uses a partially hydrolyzed mix of 60% whey and 40% casein while the Pro-Total Comfort makes use of 100% whey protein that's been partially hydrolyzed.

What is the closest formula to Similac total comfort? ›

Store Brand Complete Comfort is nutritionally comparable to Similac PRO-TOTAL COMFORT. All infant formulas sold in the United States are required to meet the same FDA standards for safety and quality. This means Store Brand Complete Comfort and the name brand are held to the same standards.

Do pediatricians recommend Similac or Enfamil? ›

Pediatricians also recommend Similac, another popular formula brand. It offers 20 different versions based on a baby's needs and dietary restrictions. Similac formulas have some added sugars, which makes it taste better but have less nutritional value. Unlike Enfamil, Similac avoids using GMOs in its ingredients.

Is it OK to switch from Similac to Enfamil? ›

1 Switching between formula brands is not a problem, even though many parents wonder if doing so may cause fussiness or stool changes in their baby. In fact, you can even mix different brands of the same type of formula together if you feel that your baby responds better to a mixture of one brand with another.

What is equivalent to Enfamil Gentlease? ›

Similac Total Comfort or Pro-Total Comfort Similac Sensitive or Pro-Sensitive Enfamil Gentlease or NeuroPro Gentlease Enfamil NeuroPro Sensitive Gerber Good Start GentlePro Gerber Good Start SoothePro **Store brand sensitive/gentle formulas ✓!

What Enfamil Gentlease is closest to? ›

Both Similac Pro-Sensitive and Enfamil Gentlease can be gentle formulas for your baby's sensitive tummy.

What is different about Similac total comfort? ›

What is the difference between Similac Pro-Total Comfort* and Similac Pro-Sensitive*? Similac Pro-Sensitive* has intact milk protein, while Similac Pro-Total Comfort* has 100% whey protein that is partially hydrolyzed as an alternative to standard intact-protein, milk-based formulas.

Why did WIC change from Enfamil to Similac? ›

California WIC is Switching Formulas Brands

California WIC is switching from Enfamil brand formula to Similac brand, as of August 1, 2022. This change is due to CDPH/WIC starting a new infant formula contract. This is because WIC is required to provide the infant formula with the best contract price.

Why did Similac total comfort get recalled? ›

These products are being recalled because some bottles in the recalled lots have bottle caps that may not have sealed completely, which could result in spoilage. If spoiled product is consumed, gastrointestinal symptoms such as diarrhea and vomiting may occur.

What formula do most pediatricians recommend? ›

Best Baby Formulas, According to Pediatricians and Parents
  • Best Baby Formula Overall : Similac Pro-Advance.
  • Best Baby Formula Overall (Tie) : Enfamil NeuroPro Infant Formula.
  • Best Organic Baby Formula : Earth's Best Organic Dairy Infant Formula.
  • Best Affordable Baby Formula : Kirkland Signature ProCare.
Jan 12, 2022

What formula is best for sensitive stomach? ›

Enter Enfamil NeuroPro Gentlease Infant Formula—a formula that has been clinically proven to reduce fussiness, crying, gas, and spit-up within 24 hours of starting. The proteins in this product are partially hydrolyzed (broken down) and easy for a sensitive tummy to handle.

How do I know if formula isn't agreeing with baby? ›

What are the Signs of Formula Intolerance?
  • Diarrhea.
  • Vomiting.
  • Blood or mucus in your baby's stool.
  • The baby often pulls her legs up toward her belly because of pain.
  • Difficulty with weight gain or noticeable weight loss.
  • Constant crying and signs of discomfort.

Can I give my baby Enfamil and Similac at the same time? ›

Most babies will do just fine with different brands of formula, including store brands, as long as they're the same type, like cow's milk-based, soy, hypoallergenic (extensively hydrolyzed), or elemental (amino acid-based).

What are the side effects of switching formula? ›

Side Effects of Changing Baby Formulas

Some babies may have side effects from switching baby formulas, but they are usually mild digestive issues, such as changes in stool. Signs a baby isn't tolerating a type of formula well include: Diarrhea, constipation, gassiness or frequent throwing up.

Why is Enfamil Gentlease better? ›

There are several differences between the two formulas, but the main difference is that Enfamil Sensitive is designed for babies who have a lactose sensitivity. Enfamil Gentlease is formulated to reduce fussiness, gas and crying.

What is special about Enfamil Gentlease? ›

Enfamil Gentlease is a 20 Cal/fl oz, milk-based infant formula designed to reduce fussiness, gas and crying. It has an easy-to-digest milk protein blend patterned after breast milk (whey and casein in a 60:40 ratio)* that has been partially broken down.

Is it OK to give my baby Enfamil Gentlease? ›

Enfamil Gentlease Infant Formula provides a gentle start for sensitive tummies. It's designed to have easy-to-digest proteins & eases fussiness, gas, and crying in just 24 hours*. Gentlease also has nutrients like choline and DHA—brain-nourishing nutrition that's important for your baby during the first 12 months.

Do babies taste like Enfamil Gentlease? ›

Enfamil A+ Gentlease® has a unique taste due to the partially hydrolyzed protein. Most infants accept the formula easily; some infants may take 3-5 days to become accustomed to the unusual taste. If this is your baby's first experience with the product, continue offering it as much as possible for several days.

What formula is the same as Similac Total Care? ›

Similac 360 Total Care

Also similar to Enfamil Neuropro and Similac Advantage. For the other store brands, see Advance/Advantage formulas. The store brands do not have a premium product. The closest would be Store Brand Advantage (one human milk oligosaccharide).

Why is Similac Total Comfort out of stock? ›

These shortages are the result of systemic supply chain problems that have resulted from the COVID pandemic. The lack of raw ingredients has forced manufacturers to slow production.

What is the closest thing to Similac formula? ›

For Similac advance powder alternative brands include Enfamil infant, Gerber good start gentle, H-E-B baby HMO advantage, Wal-Mart parent's choice infant non-GMO or Wal-Mart parent's choice advantage non-GMO.

Did they stop making Similac Total Comfort? ›

Maggie, we also wanted to let you know that we have no plans to discontinue Similac Total Comfort. This product should be available for purchase at any of the previously recommended places.

Is all Similac total comfort recalled? ›

The recalled brands include Similac, Pro-Total Comfort, Similac 360 Total Care, Similac 360 Total Care Sensitive, Similac Special Care 24, Similac Stage 1, Similac NeoSure, Similac Water (Sterilized) and Pedialyte Electrolyte Solution.

Is Similac Total Comfort being recalled? ›

October 2022 - Abbott 2 fl oz Ready-to-Feed Liquid Products

2 fl oz ready-to-feed liquid products included in this voluntary recall: US - certain lots of Similac 360 Total Care, Similac 360 Total Care Sensitive, Similac Special Care 24, Similac Pro-Total Comfort, Similac NeoSure, Pedialyte Electrolyte Solution.


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