Enfamil Gentlease vs. Similac Total Comfort [2023 Review] (2023)

Looking for an infant formula for quick relief from stomach upset? Enfamil Gentlease and Similac Total Comfort claim fast relief, but which is better?

Let us help you decide with our detailedEnfamil Gentlease versus Similac Total ComfortAnalysis!

Fidgeting during feedings can be extremely stressful for both parents and babies. It's hard when emotion follows every feeding, and taking a bottle seems to cause your child distress.

Infant formulas like Enfamil Gentlease and Similac Total Comfort offer a possible solution. These formulas are designed to be easy on the stomach as they use smaller proteins that are easier to digest. But how well do they really work?

In this guide, we take a close look at Enfamil Gentlease and Similac Total Comfort to see how the popular infant formulas perform. If sensitive stomachs are causing feeding timing issues, we think these formulas might help!

And if you love itSimilac Total Comfort versus Enfamil Gentleasecheck it out, be sure to check out our guidesbest formula that tastes like breast milk,Similac Pro Total Comfort Vs Pro Sensitive,Similac Sensitive Vs Total Comfort, EEnfamil Gentlease Vs Similac Sensitive! You might even like our reviewEnfamil NeuroPro vs. Similac Pro Advance!

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Enfamil Gentlease vs. Similac Total Comfort [2023 Review] (1)

Enfamil Gentlease vs. Similac Total Comfort

In this section, we'll look at what Enfamil Gentlease and Similac Total Comfort claim to do.

All about Enfamil Gentlease

Enfamil Gentlease vs. Similac Total Comfort [2023 Review] (2)

Enfamil Gentlease is stomach-friendly and is designed to help babies with sensitive stomachs eat a complete diet. For babies struggling with spit-up, fussiness and crying, Enfamil Gentlease can help with digestion and quickly reduce stress during feeding.

Enfamil Gentlease uses proteins that have already been partially degraded. This partially hydrolyzed non-fat milk and whey proteins pass easily through the digestive system and cause your baby less pain. If you've found that standard formulas lead to tears and excitement, Enfamil Gentlease may be an effective solution.

And you don't have to wait long to see the result! Because of these smaller proteins, you can see the benefits of switching to Gentlease in as little as 24 hours!

Enfamil Gentlease is a brain-building formula containing a special blend of choline and DHA recommended by experts. Gentlease can give your child the best start in life!


  • Enfamil Gentlease uses partially hydrolyzed proteins that are smaller and easier for the body to digest.
  • It can reduce vomiting and calm crying and fussing in babies.
  • Fast working, you can see Gentlease results in just 24 hours.
  • Contains choline and DHA, which support healthy brain development.
  • Easy to mix and with a smooth and pleasant taste.


  • Enfamil Gentlease is more expensive than similar easily digestible formulas.

You may also like our guidesEnfamil Gentlease AlternativesEbest formula for spitting and gas!

(Video) Enfamil Gentlease vs Similac Sensitive Which is Best

All about Similac Absolute comfort

Enfamil Gentlease vs. Similac Total Comfort [2023 Review] (4)

Similac Total Comfort is an infant formula developed to facilitate digestion in sensitive stomachs. As a complete food, Total Comfort uses the prebiotic 2'-FL HMO to mimic the composition of breast milk.

Similac Total Comfort uses hydrolyzed proteins to create a formula that facilitates the growth of digestive systems. This is ideal for babies who are struggling with tummy issues and find feeding time stressful. Since some of the proteins have already been digested, they put significantly less strain on the body.

As a complete food, Similac Total Comfort offers your child everything he needs for healthy growth. This food contains nutrients like DHA and Lutein for brain and eye development and gives babies a good start.

Total Comfort seems unfamiliar even with consistent use of Similac - American mothers are much more likely to recognize Similac Pro-Total Comfort! These are essentially the same formulas, only Total Comfort is made in Spain (and sold with FDA approval).

Although Similac Total Comfort is good for the stomach, some parents have found that it has a strong odor and tends to build up.


  • Made from partially hydrolyzed whey proteins that are easier to grow digestive systems.
  • Contains 2'-FL HMO, a prebiotic that supports the immune system.
  • Contains DHA and lutein for healthy brain and eye development.
  • Total Comfort does not contain palm olein oil, which can limit calcium absorption.
  • An affordable formula for sensitive stomachs.


  • Parents have found that Total Comfort tends to form lumps and needs to be mixed well.
  • Since it is an imported formula, it may be difficult to buy it from time to time, so you need to make a change to the formula.

Similac Total Comfort Infant Formula

(Video) Can I give my baby Similac total comfort?

36,49 $$ 32,97 ($ 1,14/oz)

Enfamil Gentlease vs. Similac Total Comfort [2023 Review] (5)

23.02.2023 23:51 |

Similarities and differences between Enfamil Gentlease and Similac Total Comfort

Designed to ease digestion, there are many similarities between Enfamil Gentlease and Similac Total Comfort. Here, we'll examine these similarities—and the important differences—in more detail.

A complete food for fussy babies

Enfamil Gentlease and Similac Total Comfort are formulas designed to soothe fussy tummies and soothe digestive issues. They are recommended for babies who are picky about food or who suffer from bloating and other stomach problems.

Both Enfamil Gentlease and Similac Total Comfort are packed with the nutrients your child needs for healthy growth and development. But because of the gentle formulation, they can deliver these nutrients in a way that is less likely to upset sensitive stomachs.

Whether you choose Enfamil Gentlease or Similac Total Comfort, both brands are industry leaders and have been trusted by parents for decades. Enfamil is the number one brand recommended by pediatricians, and Similac is the number one brand for hospital-fed infants. So you know your baby's feeding is in good hands!

Easily digestible proteins

What makes Enfamil Gentlease and Similac Total Comfort so good for babies with digestive problems? The key to the easy digestibility of both brands is the use of partially hydrolyzed proteins.

Hydrolysis is essentially the process of breaking down a chemical. Protein hydrolysis is used in infant formula. This makes the proteins smaller so they don't overwhelm a still-developing digestive system.

These partially hydrolyzed proteins also make formulas slightly closer to breast milk than non-hydrolyzed formulas because milk molecules are smaller.

Enfamil Gentlease uses a blend of partially hydrolyzed skim milk and concentrated whey protein solids, and Similac Total Comfort uses partially hydrolyzed whey protein.

Gentlease and Total Comfort use partial hydrolysis instead of extensive hydrolysis. They are not hypoallergenic and therefore may not be suitable for severe allergic reactions. Both also contain (very) small amounts of lactose.

Immune system support

Similac has added 2'-FL HMO to the Total Comfort formula to provide additional immune support for the growing body. 2'-FL HMO is a human milk oligosaccharide, also known as a prebiotic, which occurs naturally in breast milk. This directly helps fuel the immune response in the gut. By including 2'-FL HMO, the formula approximates breast milk for more complete nutrition.

That's not to say that Enfamil Gentlease can't support a growing immune system - it contains the nutrients your baby needs to take on the world! But Gentlease lacks the added support boost provided by the 2'-FL HMO.

Nutrients for the brain

Both Enfamil Gentlease and Similac Total Comfort contain nutrients for healthy brain development. Enfamil Gentlease offers a blend of DHA and Choline for brain support, while Similac Total Comfort uses DHA and Lutein for brain and eye development.

quick reaction

When your baby is having trouble feeding, you want to deal with it as soon as possible. Both Enfamil Gentlease and Similac Total Comfort claim to be ready to use in just 24 hours, relieving discomfort within a day of use.


This is thanks to broken down proteins, which the body can quickly adjust to.

Where is it made?

Both Similac and Enfamil are American brands and most of their formulas are made in America. However, Similac Total Comfort is an imported formula manufactured in Spain. Similac started importing Total Comfort into the US to meet supply chain needs!

Similac Total Comfort may be an imported formula, but it has been approved by the FDA for sale in the United States. It might be surprising to see imported formulas, but Similac Total Comfort had to pass the same rigorous safety checks as Enfamil Gentlease.

taste and texture

You can never tell exactly how a baby will react to formula, so don't let taste dictate your choice. However, if you're really having trouble deciding between the two, parents have found that Enfamil Gentlease has the nicest smell and taste.

While both formulas are easy to mix together, parents have found Similac Total Comfort to be more prone to lumping than Enfamil Gentlease. Gentlease dissolves better and needs less shaking during feeding.


For parents on a budget, Similac Total Comfort is usually the cheapest choice. Enfamil Gentlease is only slightly more expensive, but these small differences could result in repeat purchases.

It's often best to buy infant formula in bulk (once you know it will work for your baby). Bulk purchases avoid regular trips to the store and can often save you money. Parents may find it easier to buy Enfamil Gentlease (made in the USA) in bulk than Similac Total Comfort (imported from Spain).

Final Thoughts on Similac Total Comfort vs. Enfamil Gentlease

Enfamil Gentlease and Similac Total Comfort are formulas that use partially hydrolyzed proteins to facilitate digestion for sensitive stomachs.

Overall, we prefer the performance of the Similac Total Comfort. It contains all the nutrients needed for a complete diet, plus 2'-FL HMO, which can support immune system development. It is also typically less expensive than Enfamil Gentlease and does not contain palm olein oil.

However, Enfamil Gentlease has its advantages. It is easier to mix than Total Comfort and babies generally prefer the taste.

Sensitive stomachs can be a nightmare and both Similac Total Care and Enfamil Gentlease offer potential solutions. We hope this guide can help you when it comes to eating.

And if you want to check out more of our guides, we encourage you to check out these guides.baby food expires?,How do you keep the bottle warm at night?Ehow to warm baby bottles on the go. Or our guides to thebest bottles for tongue tie, EThe best bottles for reflux.

Enfamil Gentlease vs. Similac Total Comfort [2023 Review] (6)

buy now

(Video) Baby formula recall: How to check if your formula is safe | FOX 9 KMSP

Similac Total Comfort Infant Formula

36,49 $$ 32,97 ($ 1,14/oz)

Enfamil Gentlease vs. Similac Total Comfort [2023 Review] (7)

23.02.2023 23:51 |

Enfamil Gentlease vs. Similac Total Comfort [2023 Review] (8)

Enfamil Gentlease vs. Similac Total Comfort [2023 Review] (9)

Allison Banfield

Allison Banfield is an experienced mother of two, wife, author, editor, and passionate parenting advocate! With a Master's in Public Health, a Bachelor's in Health Promotion, a long career in health and safety and 10 years of hands-on experience using, researching and testing baby products, Allison is pleased to use her experience as a mother to provide support and encouragement to other parents.

(Video) ⏺️The Best Baby Formula: Enfamil VS Similac


Is Similac total comfort the same as Enfamil Gentlease? ›

The Winner: Similac Pro-Total Comfort

The two formulas have different protein sources, which may affect your baby's comfort: Gentlease uses a partially hydrolyzed mix of 60% whey and 40% casein while the Pro-Total Comfort makes use of 100% whey protein that's been partially hydrolyzed.

Do pediatricians recommend Similac or Enfamil? ›

Pediatricians also recommend Similac, another popular formula brand. It offers 20 different versions based on a baby's needs and dietary restrictions. Similac formulas have some added sugars, which makes it taste better but have less nutritional value. Unlike Enfamil, Similac avoids using GMOs in its ingredients.

What is equivalent to Enfamil Gentlease? ›

Similac Total Comfort or Pro-Total Comfort Similac Sensitive or Pro-Sensitive Enfamil Gentlease or NeuroPro Gentlease Enfamil NeuroPro Sensitive Gerber Good Start GentlePro Gerber Good Start SoothePro **Store brand sensitive/gentle formulas ✓!

What formula is the same as Similac Total Comfort? ›

Store Brand Complete Comfort is nutritionally comparable to Similac PRO-TOTAL COMFORT. All infant formulas sold in the United States are required to meet the same FDA standards for safety and quality. This means Store Brand Complete Comfort and the name brand are held to the same standards.

Is it OK to switch from Similac to Enfamil? ›

1 Switching between formula brands is not a problem, even though many parents wonder if doing so may cause fussiness or stool changes in their baby. In fact, you can even mix different brands of the same type of formula together if you feel that your baby responds better to a mixture of one brand with another.

What does Similac total comfort help with? ›

What does Similac Pro-Total Comfort* help with? Similac Pro-Total Comfort* with 2'-FL HMO is an easy-to-digest, gentle baby formula. It's designed for babies who have difficulty tolerating other milk-based formulas and mild tolerance symptoms, such as fussiness and gas due to lactose sensitivity.

What formula do most pediatricians recommend? ›

Best Baby Formulas, According to Pediatricians and Parents
  • Best Baby Formula Overall : Similac Pro-Advance.
  • Best Baby Formula Overall (Tie) : Enfamil NeuroPro Infant Formula.
  • Best Organic Baby Formula : Earth's Best Organic Dairy Infant Formula.
  • Best Affordable Baby Formula : Kirkland Signature ProCare.
Jan 12, 2022

What formula is best for sensitive stomach? ›

Enter Enfamil NeuroPro Gentlease Infant Formula—a formula that has been clinically proven to reduce fussiness, crying, gas, and spit-up within 24 hours of starting. The proteins in this product are partially hydrolyzed (broken down) and easy for a sensitive tummy to handle.


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